Determining the local calibration of computer-assisted detection (CAD) thresholds and other parameters

Overview

This toolkit has been developed by the Special Programme for Research and Training in Tropical Diseases (TDR) and the Global TB Programme (GTB) at WHO, in collaboration with partners and experts working on CAD and TB screening. This toolkit aims to support the implementation of computer-assisted detection (CAD) for TB screening and detection and is intended for use by national TB programmes (NTPs) and other implementers who have decided to use CAD.

The specific objectives of this toolkit are to:

• Support new users of CAD to understand threshold scores and their programmatic implications within the context of a TB screening or triage programme;

• Describe a simplified operational research protocol to collect and analyse the required data necessary to determine the appropriate CAD threshold for a specific CAD implementation;

• Support the analysis, interpretation and application of the resulting CAD diagnostic performance data and cost estimates to determine the most appropriate CAD thresholds based on local context and use case.